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Publication list Åke Sjöholm Full original papers 1. Swenne, I. & Sjöholm, Å. Effects of Retinoic Acid on Cell Proliferation, Insulin Secretion and Hexose Incorporation into Macromolecules of a Continuous, Insulin-Secreting Cell Line (RINm5F). Diab. Res. (1986) 3: 207-211.2. Welsh, N. & Sjöholm, Å. Polyamines and Insulin Production in Isolated Mouse Pancreatic Islets. Biochem. J. (1988) 252: 701-707.
3. Sandler, S., Bendtzen, K., Eizirik, D.L., Sjöholm, Å & Welsh, N. Decreased Cell Replication and Polyamine Content in Insulin-Producing Cells After Exposure to Human Interleukin 1beta. Immunol. Lett. (1989) 22: 267-272.4. Sjöholm, Å., Welsh, N., Sandler, S. & Hellerström, C. Role of Polyamines in Mitogenic and Secretory Responses of Pancreatic beta-Cells to Growth Factors. Am. J. Physiol. (1990) 259: C828-C833.
5. Dunger, A.-M., Sjöholm, Å. & Eizirik, D.L. Amino Acids and Human Amniotic Fluid Increase DNA Biosynthesis in Pancreatic Islets of Adult Mouse, but This Effect is Lost Following Exposure to Streptozotocin. Pancreas (1990) 5: 639-646.
6. Sjöholm, Å., Welsh, N., Hoftiezer, V., Bankston, P.W. & Hellerström, C. Increased Glucose Oxidation and Contents of Insulin and ATP in Polyamine-Depleted Rat Insulinoma Cells (RINm5F). Biochem. J. (1991) 277: 533-540.
7. Sjöholm, Å. & Hellerström, C. TGF-alpha Stimulates Insulin Secretion and Blocks Mitogenic Response of Pancreatic beta-Cells to Glucose. Am. J. Physiol. (1991) 260: C1046-C1051.
8. Sjöholm, Å., Arkhammar, P., Welsh, N., Bokvist, K., Rorsman, P., Hallberg, A., Nilsson, T., Welsh, M. & Berggren, P.-O. Enhanced Stimulus-Secretion Coupling In Polyamine-Depleted Rat Insulinoma Cells (RINm5F). An Effect Involving Increased Cytoplasmic Ca2+, Inositol Phosphate Generation, and Phorbol Ester Sensitivity. J. Clin. Invest. (1993) 92: 1910-1917.
9. Sjöholm, Å. Role of Polyamines in Regulation of Proliferation and Hormone Production by Insulin-Secreting Cells. Acta Univ. Ups. (1991) 296: 1-46 (Ph.D. thesis).
10. Sjöholm, Å. alpha-Adrenergic Inhibition of Rat Pancreatic beta-Cell Replication and Insulin Secretion is Mediated Through a Pertussis Toxin-Sensitive G-protein Regulating Islet cAMP Content. Biochem. Biophys. Res. Commun. (1991) 180: 152-155.
11. Sjöholm, Å. Cytokines Inhibit Proliferation and Insulin Secretion by Rat Insulinoma Cells (RINm5F) Non-Synergistically and in a Pertussis Toxin-Insensitive Manner. Immunol. Lett. (1991) 30: 81-86.
12. Sjöholm, Å. Inhibition of Fetal Rat Pancreatic beta-Cell Replication by Interleukin-1beta In Vitro is not Mediated Through Pertussis Toxin-Sensitive G-Proteins, a Decrease in Cyclic AMP, or Protease Activation. FEBS Lett. (1991) 289: 249-252.
13. Sjöholm, Å., Funakoshi, A., Efendic´, S., Östenson, C.-G. & Hellerström, C. Long-Term Inhibitory Effects of Pancreastatin and Diazepam Binding Inhibitor on Pancreatic beta-Cell DNA Replication, Insulin Secretion and Polyamine Content. Endocrinology (1991) 128: 3277-3282.
14. Sjöholm, Å. Phorbol Ester Stimulation of Pancreatic beta-Cell Replication, Polyamine Content and Insulin Secretion. FEBS Lett. (1991) 294: 257-260.
15. Sjöholm, Å., Welsh, N. & Hellerström, C. Lithium Increases DNA Replication, Polyamine Content and Insulin Secretion by Rat Pancreatic beta-Cells. Am. J. Physiol. (1992) 262: C391-C395.
16. Sjöholm, Å. Differential Effects of Cytokines on Long-Term Mitogenic and Secretory Responses of Fetal Rat Pancreatic beta-Cells. Am. J. Physiol. (1992) 263: C114-C120.
17. Sjöholm, Å. Sodium Butyrate Inhibits Insulinoma Cell Proliferation Without Affecting the Cellular Insulin Content or Insulin Release. Anticancer Drugs (1993) 4: 259-263.
18. Sjöholm, Å. Effects of Nicotinamide on the Proliferation, Polyamine Content and Insulin Secretion of Clonal Rat Insulinoma Cells. Anticancer Res. (1993) 13: 1283-1286.
19. Sjöholm, Å., Larsson, R. & Nygren, P. Difluoromethylornithine and Ethylglyoxal bis(guanylhydrazone) as Inhibitors of Human Renal Carcinoma Cell Proliferation and Polyamine Metabolism. Anticancer Res. (1993) 13: 979-984.
20. Sjöholm, Å., Honkanen, R.E. & Berggren, P.-O. Characterization of Serine/Threonine Protein Phosphatases in Insulin-Secreting Cells. Biosci. Rep. (1993) 13: 349-357.
21. Sjöholm, Å., Korsgren, O. and Andersson, A. Polyamine Requirements in Nicotinamide-Stimulated -Cell Differentiation in Fetal Porcine Islet-Like Cell Clusters. Endocrinology (1994) 135: 1559-1565.
22. Sjöholm, Å. Inhibitory Effects of Cyclosporin A on Rat Insulinoma Cell Proliferation, Polyamine Content and Insulin Secretion. Mol. Cell. Endocrinol. (1994) 99: 21-24.
23. Arkhammar, P., Juntti-Berggren, L., Larsson, O., Welsh, M., Nånberg, E., Sjöholm, Å., Köhler, M. & Berggren, P.-O. Protein Kinase C Modulates the Insulin Secretory Process by Maintaining a Proper Function of the -Cell Voltage-Activated Ca2+ Channels. J. Biol. Chem. (1994) 269: 2743-2749.
24. Dypbukt, J.M., Ankarcrona, M.M., Burkitt, M., Sjöholm, Å., Ström, K., Orrenius, S. & Nicotera, P. Different Prooxidant Levels Stimulate Growth, Trigger Apoptosis, or Produce Necrosis of Insulin-Secreting RINm5F Cells. The Role of Intracellular Polyamines. J. Biol. Chem. (1994) 269: 30553-30560.
25. Sjöholm, Å., Bucht, E., Theodorsson, E., Larsson, R. & Nygren, P. Polyamines Regulate Human Medullary Thyroid Carcinoma TT-Cell Proliferation and Secretion of Calcitonin and CGRP. Mol. Cell. Endocrinol. (1994) 103: 89-94.
26. Ämmälä, C., Eliasson, L., Bokvist, K., Berggren, P.-O., Honkanen, R.E., Sjöholm, Å., & Rorsman, P. Activation of Protein Kinases and Inhibition of Protein Phosphatases Play a Central Role in the Regulation of Exocytosis in the Pancreatic beta-cells. Proc. Natl. Acad. Sci. U.S.A. (1994) 91: 4343-434
27. Sjöholm, Å. Regulation of Rat Insulinoma Cell Proliferation and Insulin Accumulation by Peptides and Second Messengers. Ups. J. Med. Sci. (1995) 100: 201-216.
28. Sjöholm, Å. Ceramide Inhibits Pancreatic beta-Cell Insulin Production and Mitogenesis and Mimicks the Actions of Interleukin-1beta. FEBS Lett. (1995) 367: 283-286
29. Sjöholm, Å. Histaminergic Regulation of Pancreatic beta-Cell Replication and Insulin Secretion. Biochem. Biophys. Res. Commun. (1995) 214: 224-229.
30. Sjöholm, Å., Honkanen, R.E. & Berggren, P.-O. Inhibition of Serine/Threonine Protein Phosphatases by Secretagogues in Insulin-Secreting Cells. Endocrinology (1995) 136: 3391-3397.
31. Sjöholm, Å. Effects of Secretagogues on Insulin Biosynthesis and Secretion in Polyamine-Depleted Pancreatic -Cells. Am. J. Physiol. (1996) 270: C1105-C1110.
32. Sjöholm, Å. Lithium Stimulation of Rat Pancreatic beta-Cell Replication is Mediated Through Pertussis Toxin-Sensitive GTP-Binding Proteins and Occurs Independently of Ca2+ Influx, cAMP, or Protein Kinase C Activation. Diabetes (1996) 45: 1057-1062.
33. Sjöholm, Å. Effects of Transforming Growth Factor beta, Tumor Necrosis Factor alpha and Interferon gamma on Pancreatic Islet beta-Cell Responsiveness to Transforming Growth Factor Bioscience Rep. (1996) 16: 415-423.
34. Sjöholm, Å. Prostaglandins Inhibit Pancreatic beta-Cell Replication and Long-Term Insulin Secretion By Pertussis Toxin-Insensitive Mechanisms but Do Not Mediate the Actions of Interleukin-1beta. Biochim. Biophys. Acta (1996) 1313: 106-110.
35. Sjöholm, Å. Nitric Oxide Donor SIN-1 Inhibits Insulin Release. Am. J. Physiol. (1996) 271: C1098-C1102.
36. Karlson-Stiber, C., Höjer, J., Sjöholm, Å., Bluhm, G. & Salmonson, H. Nitrogen Dioxide Pneumonitis in Ice Hockey Players. J. Internal Med. (1996) 239: 451-456.
37. Sjöholm, Å. Interleukin-1beta and GTP-binding Proteins. Diabetologia (1996) 39: 243-244.
38. Sjöholm, Å. Glucose Stimulates Islet beta-Cell Mitogenesis Through GTP-Binding Proteins and by Protein Kinase C-Dependent Mechanisms. Diabetes (1997) 46: 1141-1147.
39. Larsson, O., Barker, C.J., Sjöholm, Å., Carlqvist, H., Michell, R.H., Bertorello, A., Nilsson, T., Honkanen, R., Mayr, G.W., Zwiller, J. & Berggren, P.-O. Inhibition of Phosphatases and Increased Ca2+ Channel Activity by Inositol Hexakisphosphate. Science (1997) 278: 471-474.
40. Sjöholm, Å., Lindberg, A. & Personne, M. Acute Nutmeg Intoxication. J. Internal Med. (1998) 243: 329-331
41. Sjöholm, Å. & Kindmark, H. Short and Long Term Effects of Betacellulin and Transforming Growth Factor on beta-Cell Function in Fetal Rat Pancreatic Islets. Endocrine (1999) 11: 189-193.
42. Islam, M.S., Sjöholm, Å., & Emilsson, V. Fetal Pancreatic Islets Express Functional Leptin Receptors and Leptin Stimulates Proliferation of Fetal Islet Cells. Int. J. Obesity (2000) 24: 1246-1253.
43. Sjöholm, Å., Sandberg, E., Östenson, C.-G. & Efendic´, S. Peptidergic Regulation of Maturation of the Stimulus-Secretion Coupling in Fetal beta-Cells. Pancreas (2000) 20: 282-289.
44. Sjöholm, Å. & Honkanen, R.E. Polyamines Regulate Serine/Threonine Protein Phosphatases in Insulin-Secreting Cells. Pancreas (2000) 20: 32-37.
45. Sjöholm, Å., Zhang, Q., Welsh, N., Hansson, A., Larsson, O., Tally, M. & Berggren, P.-O. Rapid Ca2+ Influx and Diacylglycerol Synthesis in Growth Hormone-Mediated Islet beta-Cell Mitogenesis. J. Biol. Chem. (2000) 275: 21033-21040.
46. Sjöholm, Å., Sandberg, E., Östenson, C.-G. & Efendic´, S. Regulation of In Vitro Maturation of the Stimulus-Secretion Coupling in Fetal Rat Islet beta-Cells. Endocrine (2000) 12: 273-278.
47. Sjöholm, Å., Berggren, P.-O., and Cooney, R.V. alpha-Tocopherol Partially Protects Insulin-Secreting Cells Against Functional Inhibition by Interleukin-1beta and Nitric Oxide. Biochem. Biophys. Res. Commun. (2000) 277: 334-40.
48. Sjöholm, Å., Arkhammar, P., Berggren, P.-O. & Andersson, A. Polyamines in Pancreatic Islets of Obese-Hyperglycemic Mice (ob/ob) of Different Ages. Am. J. Physiol. (2001) 280: C317-C323.
49. Sjöholm, Å., Berggren, P.-O. & Honkanen, R.E. Effects of Second Messengers on Serine/Threonine Protein Phosphatases in Insulin-Secreting Cells. Biochem. Biophys. Res. Commun. (2001) 283: 364-368.
50. Ekelund, S., Sjöholm, Å., Nygren, P., Binderup, L., and Larsson, R. Cellular Pharmacodynamics of the Cytotoxic Guanidino-Containing Drug CHS 828. Comparison with MGBG. Eur. J. Pharmacol. (2001) 418: 39-45.
51. Sjöholm, Å., Lehtihet, M., Efanov, A.E., Zaitsev, S.V., Berggren, P.-O., Honkanen, R.E. Glucose Metabolites Inhibit Protein Phosphatases and Promote Insulin Exocytosis in Pancreatic beta-Cells. Endocrinology (2002) 143: 4592-4598.
52. Lehtihet, M., Welsh, N., Berggren, P.-O., Cook, G.A., & Sjöholm, Å. Glibenclamide Inhibits Islet Carnitine Palmitoyltransferase I Activity, Leading to PKC-Dependent Insulin Exocytosis. Am. J. Physiol. (Endocrinol. Metab.) (2003) 285: E438-E446.
53. Nyström, T., Bratt, G., and Sjöholm, Å. Bezafibrate-induced improvement in glucose uptake and endothelial function in protease inhibitor-associated insulin resistance. J. Internal Med. (2002) 252 (6), 570-574
54. Nyström, T., Nygren, A., and Sjöholm, Å. Tetrahydrobiopterin increases insulin sensitivity in patients with type 2 diabetes and coronary heart disease. Am J Physiol (Endocrinol Metab) 2004; 287: E919-E925
55. Nyström, T., Nygren, A., and Sjöholm, Å. Persistent endothelial dysfunction is related to elevated CRP levels in type 2 diabetic patients after acute myocardial infarction. Clin. Sci. 2005; 108: 121-128.
56. Holmquist, C., Sjöholm, Å., Wolk, A., and deFaire, U. Do dietary supplements of vitamins and minerals reduce the risk for myocardial infarction among patients with diabetes mellitus? Manuscript.
57. Nyström T, Gutniak MK, Zhang Q, Zhang F, Holst JJ, Ahrén B, and Sjöholm Å. Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease. Am J Physiol (Endocrinol Metab.) 2004; 287: E1209-E-1215.
58. Lehtihet M, Honkanen RE, Sjöholm Å. Inositol hexakisphosphate and sulfonylureas regulate beta-cell protein phosphatases. Biochem. Biophys. Res. Commun. (2004) 316: 893-897.
59. Ghanaat-Pour, H., Huang, Z., Lehtihet, M., Sjöholm Å. Global expression profiling of glucose-regulated genes in pancreatic islets of spontaneosly diabetic Goto-Kakizaki rats. J. Mol. Endocrinol. (2007) 39 (2): 135-150
60. Lehtihet M, Honkanen RE, Sjöholm Å. Glutamate inhibits protein phosphatases and promotes insulin exocytosis in pancreatic beta-cells. Biochem. Biophys. Res. Commun. (2005) 328(2):601-7.
61. Huang Z, Jansson L, Sjöholm Å. Pancreatic islet blood flow is selectively enhanced by captopril, irbesartan and pravastatin, and suppressed by palmitate. Biochem. Biophys. Res. Commun. (2006);346(1):26-32.
62. Huang Z, Jansson L, Sjöholm Å. Vasoactive drugs enhance pancreatic islet blood flow, augment insulin secretion, and improve glucose tolerance in female rats. Clin. Sci. (2007) 112: 69-76.
63. Huang Z, Sjöholm Å. Ethanol acutely stimulates islet blood flow, amplifies insulin secretion, and induces hypoglycemia via NO and vagally mediated mechanisms. Endocrinology, in press.
64. Nyström, T., Gonon, A., Sjöholm, Å., and Pernow, J. Glucagon-like peptide-1 relaxes rat conduit arteries via an endothelium-independent mechanism. Reg. Peptides (2005) Feb 15;125(1-3):173-7.
65. Zhang, F., Zhang, Q., Tengholm, A., and Sjöholm, Å. Involvement of JAK2 and SrC kinases in GH-regulated Ca2+ handling and insulin secretion in insulin-secreting cells. Am. J. Physiol (Cell Physiol).(2006); 291: C466-C475. 66. Zhang F, Sjöholm Å and Zhang Q. Pioglitazone acutely influences glucose-sensitive insulin secretion in normal and diabetic human islets. Biochem. Biophys. Res. Commun. (2006); 351: 750-755.
67. Nyström, T., Nygren, A., and Sjöholm, Å. Increased levels of tumour necrosis factor-α in type 2 diabetic patients after myocardial infarction are related to endothelial dysfunction. Clin. Sci., 2006 Jun;110(6):673-81.
68. Niklasson B, Samsioe A, Blixt M, Sandler S, Sjöholm Å, Lernmark Å and Klitz W. Ljungan virus induced diabetes in adult mice depends on their intrauterine environment and post-natal stress. Diabetologia (2006) 49(9):2192-9.
69. Samsioe A, Feinstein R, Saade G, Sjöholm Å, Hörnfeldt B, Fundele R and Niklasson B. Delayed pregnancy, intrauterine deaths and malformation in Ljungan virus infected mice. Developmental and Reproductive Toxicology (2006) 77(4):251-6.
70. Hoie LH, Sjöholm Å, Guldstrand M, Zunft HJ, Lueder W, Graubaum HJ, Gruenwald J. Ultra heat treatment destroys cholesterol-lowering effect of soy protein. Int J Food Sci Nutr. 2006 Nov-Dec;57(7):512-9.
71. Hoie LH, Guldstrand M, Sjöholm Å, Graubaum HJ, Gruenwald J Zunft HJF, Luder W. Cholesterol-lowering effect of a new isolated soy protein with high levels of non-denaturated protein in hypercholesterolemic patients. Advances in Therapy 2007; 24(2):439-47.
72. Ghanaat-Pour H, Wolfram S, Kuehn N, & Sjöholm Å. Epigallocatechin gallate, a constituent of green tea, preserves pancreatic islet structure, restores insulin secretion, and ameliorates diabetes in db/db mice. Manuscript.
73. Zhang F, Sjöholm Å and Zhang Q. Attenuation of insulin secretion by insulin-like growth factor binding protein-1 in pancreatic beta-cells. Biochem. Biophys. Res. Commun. 2007; 362: 152-157.
74. Sjöholm Å. Abdominal girth and BMI are highly correlated with socio economic factors and with cardiovascular disease status. Swedish results from the global IDEA study. J. Internal Med., submitted.
75. Ghanaat-Pour H, Welsh N, & Sjöholm Å. Gene expression regulated by pioglitazone and exenatide in normal
and diabetic rat islets exposed to palmitate. Manuscript.
76. Huang Z, Jansson L, Sjöholm Å. Gender-specific regulation of pancreatic islet blood flow, insulin secretion, and glucose tolerance in spontaneously diabetic Goto-Kakizaki rats. Manuscript.
77. Zhang F, Forsberg L, Lu M, Bergström T, Bränström R, Dey D, Zhang Q, Sjöholm Å. BLX-1002, a novel thiazolidinedione with no PPAR affinity, stimulates AMP-activated protein kinase activity and enhances glucose-stimulated insulin secretion. Manuscript
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